Healthy donors

COVID-19/SARS-CoV-2 entry-associated genes:

SARS-CoV-2 entry receptor: ACE2
SARS-CoV-2 entry-associated proteases: TMPRSS2, CTSB, CTSL

Reference [1] [2]

For unpublished datasets, the included genes are:

SARS-CoV-2/SARS-CoV entry receptor: ACE2
SARS-CoV-2/SARS-CoV entry-associated proteases: TMPRSS2, CTSB, CTSL
Other cathepsins: CTSA, CTSC, CTSD, CTSE, CTSF, CTSG, CTSH, CTSK, CTSO, CTSS, CTSV, CTSW, CTSZ
Other viral receptors/receptor-associated enzymes: ANPEP (HCoV-229E), DPP4 (MERS-CoV), ST6GAL1 (Influenza), ST3GAL4 (Influenza)

Datasets

Included in the paper	Tissue	Publication	Labels	Source	HCA DCP	Technology	Contacts	Interactive viewer	H5AD
Lung and upper airway
	Nasal	Vieira Braga et al	nasal
	Bronchi	Vieira Braga et al	bronchi
	Bronchi, epithelial	Lukassen et al	bronchial epithelial cells			10x Chromium 3' v2
	Lung parenchyma	Vieira Braga et al	parenchyma
	Lung	Madissoon et al	parenchyma
	Lung parenchyma	Lukassen et al	lung			10x Chromium v2
	Fetal lung	Miller et al
	Total airway	Deprez et al
	Lung cell line - H1299	Wyler et al	Lung cell line - H1299				Emanuel Wyler
	Labels: Lung cell line - Calu-3	Wyler et al	Labels: Lung cell line - Calu-3				Emanuel Wyler
Sensory/Nervous system
	Cornea	Unpublished Queen et al.					Rachel Queen Joseph Collin Darin Zerti Majlinda Lako
	Retina	Voigt et al
	Retina	Menon et al				10x Chromium 3' v3
	Retina	Lukowski et al				10x v2
	Brain	Habib et al
	Fetal cerebellum	Aldinger, K.A., Thomson, Z., Phelps, I.G. et al.					Kimberly Aldinger email
Lymphatic system
	Fetal thymus	Park et al
	Spleen	Madissoon et al
Cardiovascular system
	Spleen	Unpublished Litviňuková et al Preprint					J. G. Seidman Christine Seidman Michela Noseda Norbert Hübner Sarah A. Teichmann
Urinary system
	Kidney	Stewart et al
Integumentary system
	Skin	Cheng et al
Reproductive system/Maternal-fetal interface
	Placenta/Decidua	Vento-Tormo et al				10x
	Placenta/Decidua	Vento-Tormo et al				SS2
	Testis	Guo et al
	Prostate	Henry et al
Digestive system
	Oesophagus	Madissoon et al
	Ileum	Martin et al
	Ileum	Wang et al
	Colon	Wang et al
	Colon, epithelial	Smillie et al
	Colon, immune cells	James et al
	Rectum	Wang et al
	Adult liver	Macparland et al
	Fetal liver	Popescu et al
	Gallbladder	Unpublished Sampaziotis et al.					Fotios Sampaziotis Ludovic Vallier
	Gingiva	Unpublished Preprint					Kevin M. Byrd
	Salivary gland	Unpublished Preprint					Blake Warner
	Integrated oral cavity (gingiva + salivary gland)	Unpublished Preprint					Kevin M. Byrd Blake Warner
	Pancreas	Baron et al

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